Dr. Griffin's sister married Albert Sidney Johnston. (See Hancock and Johnston Streets).

Created the first East Los Angeles "suburb", now known as Lincoln Heights. In 1863, he purchased 2,000 acres of ranch land for $1,000 and in 1870, Griffin and his nephew, Hancock Johnson, built homes there. In late 1874, they offered an additional 35 acres for sale, subdivided into 65 by 165 foot lots for $150 each. County Coroner (1862-1865).
Griffin was also a surgeon for Brigadier General S. W. Kearny's command on its march to California in 1846, a veteran of the Mexican War. Griffin became one of California's outstanding medical men.  He was one of the three pioneer physicians in the pueblo of Los Angeles.

OR

** J.S. Griffin's mother, Mary Hancock (she married John Caswell Griffin) was the older sister of Julia Hancock who married William Clark.  The Hancock sisters father was William Hancock, early Congressman, Rev War soldier (a Col., he reportedly had Count Pulaski die in his arms at Battle of Savannah). So the Hancock Street name could very easily have come from this source.

OR
(Most likely this would be the Lacy Street St. origin)
William Lacy founder and CEO of Lacy Pipe & Manufacturing and Puente Oil Company. At 60 years old he was considered to be in good health. He had sailed, only three weeks earlier, to Baja California aboard his 73 ft. yacht, the Penolope.  P.L. Larson was captain of the Penolope. The year was 1897. William Lacy was born in London England in 1837. He was the 5th son of a prosperous businessman. Educated as an architect, he immigrated to the USA in 1860 with his brothers. The brothers first settled in central Illinois where William married. By 1863 he'd had enough of Illinois and the Civil War so he took his wife and infant daughter and headed to California via Panama. He first settled in the San Francisco area where he was successful in business and Real Estate development. He was living in San Diego when he received his American citizenship in 1873. By 1875 William was both designing and organizing banks in Los Angeles. One of which went on to become the First National Bank of  Los Angeles. He was very active in the community serving on school boards and fire boards. By 1886 he was one of the most successful businessmen in L.A. having helped establish the second oil field in southern California.  By all standards he was the epitome of the successful capitalist businessman. 
So what  was he doing in Baja? He was doing what every successful American business man of his time was doing, exploiting the labor and land of less fortunate persons. It is not known when William acquired his holdings in Baja. There he had at least one gold mine and an ore mill. His son Ed also had a mine there. He started serious development on this property only two years before his death. What caused his death remains a mystery. His death was officially attributed to complications from appendicitis but some family members suspected foul play. After his son Ed returned home another son was to have gone to retrieve the body but it never happened. His body remains in a restored grave at the mill site near Punta Final.
Source: Robert Kinson: Searching for Lost Relatives, 5/31/02

James A. Pritchard was one of the directors of the Los Angeles Independence Railroad Company which was responsible for the first train between Los Angeles and Santa Monica in 1875.